Atropine: Multiple intravenous boluses of atropine were associated with improvement in heart rate and blood pressure in one case report. These agents most likely provided a survival benefit and improved haemodynamics.
#GLUCAGON BETA BLOCKER ANTIDOTE SERIES#
Catecholamines, inotropes and vasopressors: The use of catecholamines in treating beta-blocker toxicity was reported in 16 case reports, 3 case series and 2 animal studies. As there was concurrent utilisation of multiple interventions, it was difficult to draw definitive conclusions regarding the relative contribution of these interventions to mortality or survival. Gastric decontamination: Fifteen case reports described the administration of activated charcoal and five detailed the use of gastric lavage. Results: The risk of bias was high for all interventions. Primary outcomes included mortality and improvement in haemodynamic parameters (e.g., heart rate, blood pressure or a composite measure able to quantitate a haemodynamic response). Two reviewers screened titles and abstracts prior to selecting 141 articles (Kappa on articles included = 0.982, 95% CI 0.980-0.985).
The search strategy identified 15, 553 citations. Methods: Searches were conducted across MEDLINE (1946-26 November 2019, Ovid) Embase (1974-26 November 2019, Ovid) and the Cochrane Central Register of Controlled Trials (CENTRAL, to 26 November 2019) utilising a combination of subject headings and free text. Objective: To evaluate the effects of treatments for beta-adrenoreceptor antagonist poisoning. Introduction: Beta-adrenoreceptor antagonist (beta-blocker) poisoning is a common overdose which can lead to significant morbidity and mortality.
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